Klotho regulates CA1 hippocampal synaptic plasticity

نویسندگان
چکیده

برای دانلود رایگان متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Developmental Effects of Melatonin on Synaptic Plasticity of Hippocampal CA1 Neurons in Visual Deprived Rats

Background & Aims: Change in visual experience impairs circadian rhythms. In this study, The effects of visual deprivation during critical period of brain development and melatonin intake on synaptic plasticity of hippocampal CA1 neurons were evaluated. Methods: This experimental study was done on male rats kept in standard 12 hour light/dark condition (L...

متن کامل

The effect of ketamine on synaptic transmission and synaptic plasticity in CA1 area of rat hippocampal slices

The effect of ketamine (1-100 µM), which has NMDA receptor antagonist properties, on synaptic transmission and long-term potentiation (LTP) in CAl area of rat hippocampus was examined in vitro. Field potentials were recorded in pyramidal cell layer following Schaffer collateral stimulation. Primed-burst stimulation (PEs) was used for induction of LTP. The amplitude of population spiks (PS) was ...

متن کامل

Cellular mechanisms of synaptic plasticity in hippocampal area CA1

The coordinated activation of a number of neuronal activity-regulated kinases is required for the full expression of LTP. Modulating the efficacy of synaptic transmission, such as occurs in LTP and LTD, is thought to be a cellular mechanism for storing information in the brain. In particular, a variety of pharmacological and genetic studies have established important roles for CaMKII and ERK in...

متن کامل

Noradrenergic regulation of synaptic plasticity in the hippocampal CA1 region.

The effects of norepinephrine (NE) and related agents on long-lasting changes in synaptic efficacy induced by several patterns of afferent stimuli were investigated in the CA1 region of rat hippocampal slices. NE (10 microM) showed little effect on the induction of long-term potentiation (LTP) triggered by theta-burst-patterned stimulation, whereas it inhibited the induction of long-term depres...

متن کامل

Pannexin 1 regulates bidirectional hippocampal synaptic plasticity in adult mice

The threshold for bidirectional modification of synaptic plasticity is known to be controlled by several factors, including the balance between protein phosphorylation and dephosphorylation, postsynaptic free Ca(2+) concentration and NMDA receptor (NMDAR) composition of GluN2 subunits. Pannexin 1 (Panx1), a member of the integral membrane protein family, has been shown to form non-selective cha...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ژورنال

عنوان ژورنال: Neuroscience

سال: 2017

ISSN: 0306-4522

DOI: 10.1016/j.neuroscience.2017.02.006